It’s a bit late, so I’ll keep it short:
Dafoe is incredible…when he’s out of the suit. The suit is not good b/c the frozen face mask basically cuts off major avenues for acting. To be fair, I don’t blame anyone for that – Spiderman came out in 2002, and back then unless you were at the very bleeding edge of tech over at WETA or something like that, you couldn’t really capture faces that well.
Molina, likewise. The script sometimes gives him somewhat odd decisions for his character to make, but he sells the hell out of both the genuine, warm, mentoring scientist figure, and the twisted, embittered man who emerges from the accident.