If numbers were the only factor that mattered, wars wouldn’t be fought, you’d just compare army sizes and go home.
But more seriously, I would guess that Tywin would use the defenses of King’s Landing and the fords over the Blackwater as defensive multipliers, while using his reavers to try to cut Renly off from his supply lines. Because the thing about a giant army is that it requires an astonishing amount of resources otherwise it starts to starve to death.