To start with, I would give Spiderman villains who’ve been done before – the Green Goblin, Doc Ock, Venom, the Lizard, etc. – a bit of a rest, unless some creator has a distinct enough vision for them to warrant their use so close to the ASM movies. Hobgoblin and Jack O Lantern kind of bite the Green Goblin’s style a bit too much, so hold off on them.
Chameleon would be a great insiduous villain, not your main physical threat but a great social/mental threat. Ditto Mysterio, if you can figure out how to make his signature costume work on screen. Vermin would work as a more physical/horror threat.
And I do have a fondness for Kraven the Hunter…
RFTIT Tumblr Backup 