The main difference has to do with the relative unity of the Reach, given the relative weakness of the Tyrells’ position – so you wouldn’t see the Reach splitting during the Dance or the Blackfyre Rebellions.
But also I imagine you’d see a different relationship with the Iron Throne – whereas the Tyrells have always sought royal favor b/c of their desire for a royal marriage, the Gardeners would have been more like the Starks or the Lannisters or the Arryns.